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The embryonic precursor to the human spinal cord is the neural tube.

The neural tube is the embryonic structure that ultimately forms the brain and spinal cord. The neural tube is formed during a process called neurulation, which begins when the underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. This procedure has the potential to produce congenital malformations such as defective neural tubes.

The notochord's outermost part condenses in some places during the last embryonic growth stages to create the spine's vertebrae. The inner layer of the 3 germ layers, called the mesoderm, forms in gastrulation in the initial stages of most animals' embryonic development. The body's connective tissue plus muscle cells are developed from the mesoderm. The archenteron finally develops the digestive tract's cavity, thus the mouth appears as a new opening.

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