The nurse interprets this as tolerance developed to the analgesics.
A pharmacological notion known as drug tolerance or drug insensitivity describes peoples diminished response to a substance after repeated use. The effects of the medicine may be amplified again by increasing the dosage, although this may hasten tolerance development and further blunt the drug's effects. Drug tolerance is a sign of drug use but is not always linked to addiction or dependence. It is possible to reverse the development of tolerance by taking a drug holiday, and both physiological and psychological factors may be at play.
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