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Most psychotherapists who treated schizophrenia patients prior to the discovery of antipsychotic drugs believed that the initial task of therapy was to gain patients' trust and establish a close relationship with them.

Before the discovery of antipsychotic drugs, the most of of the handful of psychotherapists who considered schizophrenia patients believed that the first step in treatment was to gain the patients' confidence and develop a close connection with them. The advancement of antipsychotic drugs revolutionized schizophrenia treatment. Antipsychotic drugs have consistently been shown to reduce the symptoms in the most of of schizophrenia patients. Clozapine provides the most efficient antipsychotic in the treatment of therapy-resistant schizophrenia.

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