The most substantial Spanish efforts at colonization in what is now the united states took place in the Southwest.
This is further explained below.
Generally, Large-scale population movements that involve migrants maintaining strong ties with their former country, or the country of their ancestors, and, as a result of these ties, gaining substantial privileges over other inhabitants of the territory are what we mean when we talk about colonization (also spelled colonization.
In conclusion, The Spanish made significant colonization attempts in the southwestern region of what is now the United States. These efforts were concentrated in the southwest.
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