We can calculate the slope using the next formula
[tex]m=\frac{y_2-y_1}{x_2-x_1}[/tex]where
(1,-5)=(x1,y1)
(4,1)=(x2,y2)
We substitute the values into the formula above
[tex]m=\frac{1+5}{4-1}=\frac{6}{3}=2[/tex]the slope of the line is m=2, the answer is D