6) which amino acid residue replaces glutamic acid in sickle cell hemoglobin (hbshbs)? what is the pi and the migration rate of hbshbs relative to hbahba at ph 9.2 in part b?

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21-11-2022
Biology

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6) which amino acid residue replaces glutamic acid in sickle cell hemoglobin (hbshbs)? what is the pi and the migration rate of hbshbs relative to hbahba at ph 9.2 in part b?

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Valine replaces glutamic acid in sickle cell anaemia. The migration rate of HbSHBS in relation to HbAHDA at pH 9.2 is shown in Part B along with its pl.

In sickle-cell anaemia, what amino acid takes glutamic acid's place?

As a result, valine, a hydrophobic amino acid, is used in place of glutamic acid, a negatively charged sixth amino acid.

What happens when glutamic acid is used in place of valine?

Base substitution from glutamic acid to valine takes place at the appropriate location along the beta chain of the haemoglobin molecule in sickle cell anaemia. This substitution happens as a result of the beta globin gene's sixth codon's single base change from GAG to GUG.

Learn more about glutamic acid here:

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