The likelihood that this couple's subsequent child will be healthy and have 46 chromosomes A fusion of two acrocentric chromosomes is 1/3
Short Arm Variants of Acrocentric Chromosomes
Numbered 13, 14, 15, 21, and 22, respectively, are the five human acrocentric chromosomes. They all share a short, gene-poor arm that is cytogenetically identical. Their primary contribution to the cell is that the acrocentric short arms carry the NOR in subband p12, which stands for nucleolus organising regions.
Except for one investigation using fluorescent staining [Verma et al., 1977], the usual size or length of an acrocentric short arm has never been established. Idioms offered in the various iterations of the International System for Human Cytogenetic Nomenclature (ISCN) and genome browsers may provide hints.
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