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A mutation (different from normal) occurs in either the factor IX protein gene or the factor VIII protein gene in hemophilia. Too little factor VIII or IX is produced by the body as a result of the mutation.
What is hemophilia?
Blood does not clot correctly in people with hemophilia, which is typically a hereditary bleeding illness. Both spontaneous bleeding and bleeding after injury or surgery may result from this. Blood has a large number of clotting proteins that can halt bleeding. Low amounts of factor VIII or factor IX are seen in those with hemophilia. The quantity of factor in the blood determines how severe a person's hemophilia is. Bleeding is more likely to happen, which can cause major health issues, the smaller the level of the component.
Later in adulthood, hemophilia can very seldom strike a person. In the majority of cases, middle-aged or elderly individuals as well as young women who have recently given birth or are in the latter stages of pregnancy are involved. With the right care, this illness often improves.
A gene that codes for the clotting factor proteins necessary to create a blood clot is altered or mutated in haemophilia, which results in the disorder. A clotting protein that has undergone this alteration or mutation may not function at all or may function improperly. On the X chromosome, these genes are located. XY chromosomes are found in males and females, with males having one and females having two (XX). The X and Y chromosomes are passed down to males from their mothers and fathers, respectively. Each parent contributes one X chromosome to females.
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What causes hemophilia type A?.
