An individual who is heterozygous for the sickle-cell trait will display some disease symptoms (Option-b). It is a widespread illness.
Red blood cells with sickle cell disease are distorted, losing their characteristic circular shape.
Sickle cell disease is a genetic condition brought on by mutations that can be passed down through the generations.
Because sickle cell disease is a codominant condition, heterozygous people who have both normal and defective alleles express it.
Therefore, compared to normal homozygotes, heterozygotes are more resistant to the incapacitating effects of malaria. In many sickle-cell carriers, this heterozygote advantage outweighs the severe reproductive disadvantage of the more uncommon sickle-cell homozygotes.
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