Why are receptors for steroid hormones located inside the cell rather than on the membrane surface?

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21-07-2017
Biology

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Why are receptors for steroid hormones located inside the cell rather than on the membrane surface?

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budwilkins budwilkins · Answer 1 · 2017-07-21T15:46:12+02:00

Steroid hormones are built around a cholesterol backbone, which is a lipid. Since the majority of the thickness of the cell membrane is composed of hydrophobic fatty acid tails, steroid hormones, also being hydrophobic (or lipophilic), can easily pass through the cell membrane to seek out intracellular/extranuclear receptors. This process allows these types of hormones to bypass the membrane-coupled second messenger systems (G-protein/cAMP/IP3, etc.) to more quickly and effectively initiate their effects on the nucleus or other internal component(s) of the cell.

luisvaschetto luisvaschetto · Answer 2 · 2021-11-05T13:42:18+01:00

The receptors for steroid hormones are located inside the cell because these hormones are lipid-soluble and therefore they can diffuse across the lipid bilayer.

Steroid hormones are lipid-soluble hormones generated from cholesterol in the gonads and the adrenal gland.

Steroid hormones are classified as glucocorticoids, androgens, corticoids, and progestagens.

Some examples of steroid hormones include testosterone and progesterone.

These hormones (steroid hormones) can easily pass across the hydrophobic interior of cell membranes.

In conclusion, the receptors for steroid hormones are located inside the cell because these hormones are lipid-soluble and therefore they can diffuse across the lipid bilayer.

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