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Nonsteroidal anti-inflammatory drugs (NSAIDs) are generally advised to be avoided during early gestation, particularly in the third trimester, due to potential teratogenic effects. Prolonged use of NSAIDs, especially during the first and second trimesters, has been associated with an increased risk of certain congenital abnormalities. These teratogenic effects may include an increased risk of heart defects, particularly septal heart defects.

It's important for pregnant individuals to consult with healthcare professionals before using any medications during pregnancy to ensure the well-being of both the mother and the developing fetus.