A substantial body of research has shown that the main neuromodulatory neurotransmitters dopamine (DA), norepinephrine (NE), and acetylcholine (ACh) affect LTP magnitude at the cellular level.
After long-term potentiation has taken place, what happens?
- There are more AMPA receptor sites present when long-term potentiation takes place, but the presynaptic neuron also appears to undergo long-lasting modifications. After the long-term potentiation has been established, the terminal buttons of the neurons involved release more neurotransmitter.
- It is believed that a key mechanism underlying learning and memory is long-term potentiation (LTP) of synaptic effectiveness. A substantial body of research has shown that the main neuromodulatory neurotransmitters dopamine (DA), norepinephrine (NE), and acetylcholine (ACh) affect LTP magnitude at the cellular level.
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